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The goal is to determine both the variability AND the equivalency of the new assay results vs the original assay. This is especially important if the results from the old and new assay are to be combined for future lead selection and/or SAR analysis.

The characterization of allosteric modulators requires significantly more effort than traditional drugs as the models contain many more parameters that, in-turn, require more sophisticated experiments and data analysis.

February 2, 2018

A specific usage of MSR is for monitoring production assay results on an ongoing basis. All that is required to do this is that a reference compound be included in each assay run.

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Monitoring Assay Variability Using Minimum Significant Ratio

February 2, 2018

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